BAX

Across TCGA cell cohorts, BAX RNA expression is significantly associated with the go_rna of many other GO terms, with 3,754 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible BAX-associated GO terms across cancer lineages are Protein depolymerization, MAPK cascade, and Peptidyl-lysine monomethylation. Each is linked with BAX in more than 10 cancer types. Because this analysis shows association rather than direction, both BAX-to-partner and partner-to-BAX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein depolymerization grouped by BAX-low versus BAX-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BAX→partner) and Y-score (partner→BAX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Protein depolymerization →	+0.112	+0.637	<.001	.007	3	11
LUNG_NSCLC_LUAD	MAPK cascade →	+0.036	+0.597	.006	.006	3	9
URINARY_TRACT	Peptidyl-lysine monomethylation →	-0.110	-1.154	<.001	<.001	3	9
BONE	Regulation of ATP metabolic process →	+0.063	+0.993	.006	.002	3	9
SKIN	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.085	+1.077	.006	.004	3	9
UPPER_AERODIGESTIVE_TRACT	Negative regulation of calcium ion export across plasma membrane →	+0.090	+0.732	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,754 associations by consensus.

Protein depolymerization by BAX expression — UPPER_AERODIGESTIVE_TRACT

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