BAX

Across TCGA cell cohorts, BAX mutation is significantly associated with the RNA expression of many other genes, with 397 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BAX-associated genes across cancer lineages are BHMT, GZMK, and GRM6. Each is linked with BAX in more than 1 cancer types. Because this analysis shows association rather than direction, both BAX-to-partner and partner-to-BAX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BHMT grouped by BAX-low versus BAX-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BAX→partner) and Y-score (partner→BAX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BHMT →	+0.292	+2.584	.005	.004	3	2
BLOOD_Leukemia	GZMK →	+0.418	+3.359	.001	.002	3	1
BLOOD_Leukemia	GRM6 →	+0.030	+3.177	<.001	.004	3	1
BLOOD_Leukemia	VSX2 →	+0.029	+3.258	<.001	.007	3	1
BLOOD_Leukemia	KIAA0319 →	+0.192	+3.378	<.001	.008	3	1
BLOOD_Leukemia	SERPINA10 →	+0.067	+3.540	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 397 associations by consensus.

BHMT by BAX expression — LARGE_INTESTINE

Explore this box plot interactively →