BARD1

Across TCGA patient cohorts, BARD1 mutation is significantly associated with the RNA expression of many other genes, with 1,763 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BARD1-associated genes across cancer lineages are GPHB5, NMS, and BCRP7. Each is linked with BARD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BARD1-to-partner and partner-to-BARD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPHB5 grouped by BARD1-low versus BARD1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BARD1→partner) and Y-score (partner→BARD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	GPHB5 →	+0.115	+3.996	<.001	.002	3	2
PRAD	NMS →	+0.158	+5.294	<.001	.001	3	2
HNSC	BCRP7 →	+0.074	+3.240	.009	.009	3	2
LUAD	LINC01941 →	+0.118	+4.157	<.001	.002	3	2
UCEC	TRAJ10 →	+0.443	+1.617	.002	.008	3	2
BLCA	ZNF519P1 →	+0.027	+3.762	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,763 associations by consensus.

GPHB5 by BARD1 expression — BLCA

Explore this box plot interactively →