BARD1

Across TCGA patient cohorts, BARD1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BARD1-associated genes across cancer lineages are Src_pY527, MEK1, and PCNA. Each is linked with BARD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both BARD1-to-partner and partner-to-BARD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src_pY527 grouped by BARD1-low versus BARD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BARD1→partner) and Y-score (partner→BARD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Src_pY527 →	-0.506	-2.797	.002	.003	3	3
UCEC	MEK1 →	+0.289	+2.087	.039	.005	3	2
UCEC	PCNA →	+0.277	+3.584	<.001	.002	3	2
UCEC	PKC-a →	+0.324	+2.335	.037	.018	3	2
UCEC	4E-BP1_pT37_T46 →	-0.339	-1.861	.018	.049	3	2
UCEC	c-Jun_pS73 →	-0.130	-3.156	.032	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Src_pY527 by BARD1 expression — UCEC

Explore this box plot interactively →