BARD1

Across TCGA cell cohorts, BARD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,735 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BARD1-associated GO terms across cancer lineages are Regulation of G2/M transition of mitotic cell cycle, Regulation of chromosome separation, and Regulation of centrosome duplication. Each is linked with BARD1 in more than 18 cancer types. Because this analysis shows association rather than direction, both BARD1-to-partner and partner-to-BARD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of G2/M transition of mitotic cell cycle grouped by BARD1-low versus BARD1-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BARD1→partner) and Y-score (partner→BARD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Regulation of G2/M transition of mitotic cell cycle →	+0.076	+1.268	<.001	<.001	3	19
BREAST	Regulation of chromosome separation →	+0.172	+1.070	<.001	<.001	3	19
URINARY_TRACT	Regulation of centrosome duplication →	+0.089	+1.001	<.001	.001	3	18
UPPER_AERODIGESTIVE_TRACT	Negative regulation of cell cycle process →	+0.081	+1.003	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Negative regulation of G2/M transition of mitotic cell cycle →	+0.112	+1.218	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Negative regulation of cell cycle phase transition →	+0.086	+1.037	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,735 associations by consensus.

Regulation of G2/M transition of mitotic cell cycle by BARD1 expression — BLOOD_Lymphoma

Explore this box plot interactively →