BAP1

Across TCGA cell cohorts, BAP1 mutation is significantly associated with the RNA expression of many other genes, with 385 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BAP1-associated genes across cancer lineages are TTC24, SPACA5, and ALDH6A1. Each is linked with BAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BAP1-to-partner and partner-to-BAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTC24 grouped by BAP1-low versus BAP1-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BAP1→partner) and Y-score (partner→BAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TTC24 →	+0.080	+3.807	<.001	.003	3	2
BLOOD_Leukemia	SPACA5 →	+0.143	+4.230	<.001	<.001	3	2
LARGE_INTESTINE	ALDH6A1 →	+0.905	+3.064	.003	.009	3	2
KIDNEY	MMP20 →	+0.094	+3.584	.004	.004	3	1
KIDNEY	C17orf99 →	+0.038	+2.947	.007	.009	3	1
BLOOD_Leukemia	ELOA3CP →	+0.137	+2.789	<.001	.008	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 385 associations by consensus.

TTC24 by BAP1 expression — KIDNEY

Explore this box plot interactively →