BANK1

Across TCGA patient cohorts, BANK1 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BANK1-associated genes across cancer lineages are JNK_pT183_Y185, Cyclin-B1, and Mre11. Each is linked with BANK1 in more than 3 cancer types. Because this analysis shows association rather than direction, both BANK1-to-partner and partner-to-BANK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by BANK1-low versus BANK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BANK1→partner) and Y-score (partner→BANK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.154	-2.222	.007	.010	3	3
UCEC	Cyclin-B1 →	+0.708	+2.137	<.001	.001	2	4
UCEC	Mre11 →	-0.061	-1.247	.036	.045	3	2
UCEC	Caspase-7-cleavedD198 →	+0.875	+2.523	<.001	<.001	3	2
UCEC	CDK1 →	+0.119	+1.750	.020	.049	3	2
COAD	4E-BP1 →	+0.241	+3.330	.019	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

JNK_pT183_Y185 by BANK1 expression — UCEC

Explore this box plot interactively →