BAG3

Across TCGA pan-cancer cohorts, BAG3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated BAG3 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher BAG3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated BAG3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

CCRCC, LSCC, and LUAD are the cancer types where BAG3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.418	0.732	.006	16	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.867	.023	6	view →
LUAD	DFS	Quartile	II,III,IV	0.154	1.000	.003	6	view →
HNSC	DFS	Tertile	III,IV	1.000	0.911	.032	2	view →
UCEC	DFS	Tertile	All	0.941	0.836	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

BAG3–CCRCC (DFS)

Open the CCRCC breakdown →