BAG3

Across TCGA patient cohorts, BAG3 protein abundance is significantly associated with the RNA expression of many other genes, with 12,974 significant associations in total. COAD shows the largest number of these associations.

The most reproducible BAG3-associated genes across cancer lineages are HSPB8, PRC1-AS1, and PTGER3. Each is linked with BAG3 in more than 8 cancer types. Because this analysis shows association rather than direction, both BAG3-to-partner and partner-to-BAG3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BAG3 versus HSPB8 in BRCA, with a Pearson correlation of 0.63.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BAG3→partner) and Y-score (partner→BAG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HSPB8 →	+1.912	+0.573	<.001	<.001	3	9
HNSC	PRC1-AS1 →	-0.524	-0.249	<.001	<.001	3	6
UCEC	PTGER3 →	+1.617	+0.466	<.001	<.001	3	6
GBM	KIAA0930 →	+0.635	+0.551	<.001	.001	3	5
GBM	ANXA7 →	+0.621	+0.832	<.001	<.001	3	5
COAD	PI4K2A →	+0.384	+0.253	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,974 associations by consensus.

BAG3 vs HSPB8 — BRCA

Explore this scatter interactively →