BAG3

Across TCGA patient cohorts, BAG3 mutation is significantly associated with the RNA expression of many other genes, with 1,063 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BAG3-associated genes across cancer lineages are RN7SL754P, RN7SL419P, and RNU2-31P. Each is linked with BAG3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BAG3-to-partner and partner-to-BAG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL754P grouped by BAG3-low versus BAG3-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BAG3→partner) and Y-score (partner→BAG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RN7SL754P →	+0.211	+4.449	<.001	.002	3	2
HNSC	RN7SL419P →	+0.149	+3.916	<.001	.006	3	2
COAD	RNU2-31P →	+0.559	+5.547	.001	.002	3	2
UCEC	RNU6-668P →	+0.263	+2.601	<.001	.005	3	2
UCEC	RPL34P3 →	+0.101	+2.474	.005	.001	3	2
UCEC	MIR7702 →	+0.163	+3.738	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,063 associations by consensus.

RN7SL754P by BAG3 expression — HNSC

Explore this box plot interactively →