BAG2

Across TCGA patient cohorts, BAG2 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BAG2-associated genes across cancer lineages are FoxM1, JNK_pT183_Y185, and JNK2. Each is linked with BAG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BAG2-to-partner and partner-to-BAG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by BAG2-low versus BAG2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BAG2→partner) and Y-score (partner→BAG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.354	+2.321	.006	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.213	-2.308	.011	.036	3	1
UCEC	JNK2 →	+0.269	+2.321	.007	.035	3	1
UCEC	MEK1 →	+0.525	+3.459	.004	.005	3	1
UCEC	STAT3_pY705 →	-0.442	-2.321	<.001	.035	3	1
UCEC	VHL →	-1.592	-3.321	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

FoxM1 by BAG2 expression — UCEC

Explore this box plot interactively →