BAG2

Across TCGA pan-cancer cohorts, BAG2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of BAG2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where BAG2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BAG2 is over-expressed in tumor, although a few such as THCA and BLCA show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where BAG2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BAG2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	+1.215	<.001	11	view →
THCA	Female	All	−0.875	<.001	10	view →
LIHC	Male	II,III,IV	+1.615	<.001	9	view →
BLCA	Male	All	−2.497	<.001	8	view →
LUAD	Male	All	+0.808	<.001	8	view →
KIRC	All	All	−0.501	<.001	7	view →
KICH	Female	II,III,IV	−1.312	<.001	5	view →
STAD	Female	All	−2.032	.011	2	view →
UCEC	All	All	−1.149	.004	2	view →
READ	Female	All	−2.139	.041	1	view →
LUSC	Female	III,IV	−1.085	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

BAG2–HNSC

Open the HNSC breakdown →