BAD

Across TCGA pan-cancer cohorts, BAD mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of BAD’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where BAD mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types BAD is over-expressed in tumor, although a few such as COAD and CCRCC show the opposite, repressed pattern.

COAD, CCRCC, and HNSC are the cancer types where BAD tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BAD mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	−0.336	<.001	8	view →
CCRCC	Female	All	−0.302	<.001	8	view →
HNSC	All	All	−0.155	.013	8	view →
LSCC	Male	II,III,IV	−0.224	<.001	6	view →
PDAC	Female	II,III,IV	+0.460	<.001	2	view →
OV	All	All	−0.447	.015	2	view →
LUAD	All	All	+0.089	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

BAD–COAD

Open the COAD breakdown →