BAD

Across TCGA patient cohorts, BAD mutation is significantly associated with the RNA expression of many other genes, with 145 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BAD-associated genes across cancer lineages are HNRNPA1P29, MYLK-AS2, and RNA5SP422. Each is linked with BAD in more than 1 cancer types. Because this analysis shows association rather than direction, both BAD-to-partner and partner-to-BAD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HNRNPA1P29 grouped by BAD-low versus BAD-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BAD→partner) and Y-score (partner→BAD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HNRNPA1P29 →	+0.080	+4.913	<.001	.002	3	2
UCEC	MYLK-AS2 →	+0.319	+3.954	<.001	<.001	3	2
UCEC	RNA5SP422 →	+1.133	+2.408	<.001	.009	3	2
SKCM	CTBP2P10 →	+0.031	+5.993	<.001	.001	3	1
CESC	RPL7P34 →	+0.047	+5.103	.006	.008	3	1
CESC	RNU7-55P →	+0.476	+6.569	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 145 associations by consensus.

HNRNPA1P29 by BAD expression — SKCM

Explore this box plot interactively →