BAD

Across TCGA patient cohorts, BAD mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BAD-associated genes across cancer lineages are C-Raf_pS338, Cyclin-B1, and HER3. Each is linked with BAD in more than 1 cancer types. Because this analysis shows association rather than direction, both BAD-to-partner and partner-to-BAD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf_pS338 grouped by BAD-low versus BAD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BAD→partner) and Y-score (partner→BAD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf_pS338 →	-0.117	-3.000	.013	.037	3	1
UCEC	Cyclin-B1 →	+0.750	+3.000	.020	.037	3	1
UCEC	HER3 →	+0.535	+3.013	<.001	.019	1	2
UCEC	Lck →	-0.245	-3.000	.035	.037	2	1
UCEC	eIF4E →	+0.247	+3.000	.042	.037	1	1
UCEC	PDCD4 →	-0.663	-3.000	.014	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

C-Raf_pS338 by BAD expression — UCEC

Explore this box plot interactively →