BACH1

Across TCGA patient cohorts, BACH1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BACH1-associated genes across cancer lineages are MEK1, PDCD4, and ASNS. Each is linked with BACH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BACH1-to-partner and partner-to-BACH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by BACH1-low versus BACH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BACH1→partner) and Y-score (partner→BACH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.466	+2.273	<.001	<.001	3	2
UCEC	PDCD4 →	-0.569	-1.999	<.001	<.001	3	2
UCEC	ASNS →	+0.260	+1.125	.017	.033	3	2
UCEC	EGFR_pY1068 →	-0.247	-1.754	.001	.001	3	1
UCEC	eIF4E →	+0.179	+2.247	.004	.001	3	1
UCEC	FoxM1 →	+0.167	+1.754	.033	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

MEK1 by BACH1 expression — UCEC

Explore this box plot interactively →