BACH1

Across TCGA pan-cancer cohorts, BACH1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of BACH1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where BACH1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BACH1 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

HNSC, KIRP, and KIRC are the cancer types where BACH1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BACH1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.711	<.001	10	view →
KIRP	All	II,III,IV	+0.904	.004	7	view →
KIRC	Male	All	+0.537	<.001	7	view →
KICH	Female	All	−1.103	<.001	5	view →
ESCA	All	All	+0.803	.022	2	view →
UCEC	All	All	−0.746	.002	2	view →
PRAD	All	All	+0.518	<.001	2	view →
CHOL	Male	All	+1.081	.002	1	view →
COAD	Male	All	+0.306	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

BACH1–HNSC

Open the HNSC breakdown →