BACH1

Across TCGA cell cohorts, BACH1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible BACH1-associated genes across cancer lineages are IL2, VWC2, and C9orf92. Each is linked with BACH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BACH1-to-partner and partner-to-BACH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL2 grouped by BACH1-low versus BACH1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BACH1→partner) and Y-score (partner→BACH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	IL2 →	+0.031	+3.734	.001	.006	3	2
BLOOD_Leukemia	VWC2 →	+0.417	+3.551	<.001	.009	3	1
BLOOD_Leukemia	C9orf92 →	+0.102	+5.124	<.001	<.001	3	1
LARGE_INTESTINE	ACER1 →	+0.087	+3.145	.001	.004	3	1
LARGE_INTESTINE	C9orf153 →	+0.249	+3.497	<.001	.004	3	1
LARGE_INTESTINE	CFHR2 →	+0.032	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

IL2 by BACH1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →