BACH1-IT3

Across TCGA pan-cancer cohorts, BACH1-IT3 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated BACH1-IT3 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher BACH1-IT3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated BACH1-IT3 expression acts as an unfavorable survival marker, although some lineages such as ESCA and LAML show a favorable association.

UVM, KIRC, and SKCM are the cancer types where BACH1-IT3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.292	0.864	<.001	108	view →
KIRC	DFS	Tertile	IV	0.291	0.711	<.001	62	view →
SKCM	OS	Tertile	IV	0.216	0.666	.002	48	view →
THCA	OS	Tertile	II,III,IV	0.295	0.920	<.001	27	view →
KIRP	OS	Tertile	II,III,IV	0.643	0.883	.024	18	view →
LUAD	OS	Tertile	IV	0.416	0.733	.031	18	view →
READ	DFS	Tertile	All	0.549	0.852	.008	18	view →
LUSC	DFS	Tertile	All	0.526	0.667	.015	15	view →
ESCA	DFS	Tertile	IV	0.692	0.242	.024	12	view →
LAML	DFS	Quartile	All	0.628	0.249	.003	10	view →
OV	OS	Median	III,IV	0.361	0.273	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

BACH1-IT3–UVM (OS)

Open the UVM breakdown →