BACH1-IT3

Across TCGA pan-cancer cohorts, BACH1-IT3 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of BACH1-IT3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where BACH1-IT3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BACH1-IT3 is over-expressed in tumor.

HNSC, ESCA, and BRCA are the cancer types where BACH1-IT3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BACH1-IT3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.044	.014	4	view →
ESCA	All	II,III,IV	+0.514	.029	2	view →
BRCA	Female	All	+0.168	.038	2	view →
KIRC	Female	All	+0.049	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

BACH1-IT3–HNSC

Open the HNSC breakdown →