BACH1-IT2

Across TCGA pan-cancer cohorts, BACH1-IT2 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated BACH1-IT2 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher BACH1-IT2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated BACH1-IT2 expression acts as an unfavorable survival marker, although some lineages such as UCS and THCA show a favorable association.

KIRC, ACC, and MESO are the cancer types where BACH1-IT2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.558	0.685	<.001	205	view →
ACC	DFS	Tertile	II,III,IV	0.334	0.705	<.001	81	view →
MESO	OS	Tertile	All	0.250	0.554	<.001	64	view →
UCS	DFS	Quartile	II,III,IV	0.577	0.077	<.001	42	view →
LGG	DFS	Median	All	0.648	0.812	<.001	38	view →
SARC	OS	Median	All	0.387	0.610	<.001	26	view →
LIHC	DFS	Tertile	All	0.376	0.498	.004	26	view →
LUAD	DFS	Median	IV	0.338	0.619	.023	25	view →
UVM	DFS	Quartile	II,III,IV	0.340	0.705	.004	17	view →
PRAD	DFS	Tertile	All	0.737	0.901	.003	16	view →
THCA	DFS	Tertile	III,IV	0.931	0.423	.017	15	view →
UCEC	DFS	Quartile	All	0.868	0.934	.012	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

BACH1-IT2–KIRC (DFS)

Open the KIRC breakdown →