BACH1-IT2

Across TCGA pan-cancer cohorts, BACH1-IT2 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of BACH1-IT2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where BACH1-IT2 RNA is repressed in tumor relative to normal tissue. In most cancer types BACH1-IT2 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KICH, LIHC, and STAD are the cancer types where BACH1-IT2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BACH1-IT2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	III,IV	−0.325	<.001	10	view →
LIHC	All	II,III,IV	+0.163	.001	6	view →
STAD	Male	II,III,IV	+0.288	.001	4	view →
UCEC	All	II,III,IV	+0.251	.005	4	view →
BLCA	Female	IV	+0.370	.002	2	view →
CHOL	Male	All	+0.328	.002	2	view →
BRCA	All	III,IV	−0.168	.005	2	view →
KIRC	All	All	+0.060	.025	2	view →
THCA	Male	All	+0.125	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

BACH1-IT2–KICH

Open the KICH breakdown →