BACH1-IT1

Across TCGA pan-cancer cohorts, BACH1-IT1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated BACH1-IT1 data layer compared with 2 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher BACH1-IT1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated BACH1-IT1 expression acts as an unfavorable survival marker, although some lineages such as UCS and CHOL show a favorable association.

KIRC, ACC, and UCS are the cancer types where BACH1-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	All	0.514	0.775	<.001	92	view →
ACC	DFS	Median	All	0.256	0.640	<.001	79	view →
UCS	DFS	Quartile	III,IV	0.689	0.142	<.001	66	view →
UVM	DFS	Tertile	All	0.372	0.897	.004	64	view →
LIHC	DFS	Tertile	All	0.388	0.625	<.001	52	view →
BLCA	OS	Tertile	All	0.519	0.805	<.001	38	view →
THCA	OS	Median	II,III,IV	0.786	0.966	.001	38	view →
KIRP	DFS	Median	III,IV	0.138	0.664	.003	34	view →
LGG	OS	Quartile	All	0.724	0.854	.007	31	view →
MESO	OS	Median	All	0.286	0.479	.001	28	view →
SARC	DFS	Tertile	All	0.411	0.743	<.001	23	view →
PCPG	DFS	Median	All	0.818	0.950	.009	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

BACH1-IT1–KIRC (DFS)

Open the KIRC breakdown →