BACH1-IT1

Across TCGA pan-cancer cohorts, BACH1-IT1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of BACH1-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where BACH1-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BACH1-IT1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, KICH, and LIHC are the cancer types where BACH1-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BACH1-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.297	.001	10	view →
KICH	Female	III,IV	−0.946	<.001	8	view →
LIHC	All	III,IV	+0.233	.001	8	view →
BLCA	All	III,IV	+0.574	.005	6	view →
UCEC	All	II,III,IV	+0.379	.015	4	view →
KIRC	Male	IV	+0.248	.018	4	view →
THCA	Male	III,IV	−0.204	.017	3	view →
COAD	All	All	+0.163	.022	3	view →
CHOL	Male	All	+0.690	<.001	2	view →
PRAD	All	All	+0.237	.010	2	view →
BRCA	All	III,IV	−0.214	.029	2	view →
LUAD	All	III,IV	−0.294	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

BACH1-IT1–HNSC

Open the HNSC breakdown →