B4GALNT4

Across TCGA pan-cancer cohorts, B4GALNT4 RNA is linked to patient survival in 30 of 34 cancer types, making it the most broadly survival-associated B4GALNT4 data layer compared with 7 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher B4GALNT4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated B4GALNT4 expression acts as an unfavorable survival marker, although some lineages such as PAAD and ESCA show a favorable association.

KIRC, KIRP, and ACC are the cancer types where B4GALNT4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.554	0.699	<.001	105	view →
KIRP	DFS	Median	All	0.781	0.919	<.001	98	view →
ACC	DFS	Tertile	All	0.210	0.655	<.001	78	view →
MESO	DFS	Tertile	III,IV	0.249	0.546	.002	49	view →
UVM	DFS	Tertile	All	0.364	0.813	<.001	35	view →
PAAD	OS	Median	All	0.497	0.279	.003	33	view →
LUSC	OS	Tertile	III,IV	0.270	0.864	.008	29	view →
THCA	OS	Median	III,IV	0.945	1.000	.005	28	view →
PRAD	DFS	Median	All	0.679	0.896	<.001	24	view →
ESCA	OS	Median	IV	0.698	0.222	.006	22	view →
COAD	DFS	Quartile	II,III,IV	0.666	0.833	.001	21	view →
UCEC	DFS	Median	All	0.805	0.868	.016	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

B4GALNT4–KIRC (OS)

Open the KIRC breakdown →