B4GALNT2

Across TCGA patient cohorts, B4GALNT2 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible B4GALNT2-associated genes across cancer lineages are HER3, p38-MAPK, and mTOR_pS2448. Each is linked with B4GALNT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both B4GALNT2-to-partner and partner-to-B4GALNT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3 grouped by B4GALNT2-low versus B4GALNT2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (B4GALNT2→partner) and Y-score (partner→B4GALNT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HER3 →	+0.425	+3.321	.012	.009	3	2
SKCM	p38-MAPK →	-0.207	-2.983	.003	.034	3	2
UCEC	mTOR_pS2448 →	-0.134	-1.986	.022	.029	3	2
UCEC	PDCD4 →	-0.475	-1.584	.010	.036	3	2
UCEC	STAT3_pY705 →	-0.515	-3.906	<.001	<.001	3	2
UCEC	53BP1 →	+0.272	+2.999	.043	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

HER3 by B4GALNT2 expression — SKCM

Explore this box plot interactively →