B3GNT7

Across TCGA pan-cancer cohorts, B3GNT7 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated B3GNT7 data layer compared with 2 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher B3GNT7 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated B3GNT7 expression acts as an unfavorable survival marker, although some lineages such as COAD and THCA show a favorable association.

UVM, LGG, and COAD are the cancer types where B3GNT7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	II,III,IV	0.430	0.840	<.001	81	view →
LGG	DFS	Median	All	0.643	0.828	<.001	53	view →
COAD	DFS	Tertile	III,IV	0.747	0.318	.002	45	view →
THCA	OS	Quartile	II,III,IV	1.000	0.859	.002	44	view →
LUSC	DFS	Median	All	0.701	0.813	<.001	42	view →
HNSC	DFS	Tertile	IV	0.755	0.526	.002	33	view →
SKCM	OS	Tertile	II,III,IV	0.425	0.211	.005	29	view →
KIRC	DFS	Median	IV	0.367	0.653	.002	16	view →
KIRP	OS	Median	III,IV	0.233	0.638	.003	14	view →
READ	DFS	Quartile	IV	0.751	0.296	.011	12	view →
CHOL	OS	Quartile	All	1.000	0.203	.014	9	view →
CESC	OS	Tertile	III,IV	0.692	0.262	.026	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

B3GNT7–UVM (OS)

Open the UVM breakdown →