B3GNT4

Across TCGA pan-cancer cohorts, B3GNT4 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated B3GNT4 data layer compared with 2 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher B3GNT4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated B3GNT4 expression acts as an unfavorable survival marker, although some lineages such as SCLC and STAD show a favorable association.

ACC, MESO, and HNSC are the cancer types where B3GNT4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	II,III,IV	0.737	0.948	<.001	106	view →
MESO	OS	Tertile	III,IV	0.372	0.677	<.001	99	view →
HNSC	DFS	Median	All	0.651	0.763	.001	94	view →
COAD	OS	Tertile	IV	0.362	0.809	<.001	81	view →
SKCM	OS	Median	II,III,IV	0.658	0.799	<.001	63	view →
UVM	DFS	Tertile	II,III,IV	0.570	0.859	.005	46	view →
BLCA	DFS	Quartile	IV	0.177	0.817	.001	44	view →
LIHC	DFS	Tertile	All	0.330	0.487	<.001	40	view →
KIRP	DFS	Tertile	III,IV	0.240	0.734	.004	38	view →
BRCA	DFS	Quartile	III,IV	0.789	0.918	.015	21	view →
PRAD	DFS	Quartile	All	0.887	0.977	.001	16	view →
UCS	DFS	Median	II,III,IV	0.273	0.586	.007	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

B3GNT4–ACC (OS)

Open the ACC breakdown →