B3GNT4

Across TCGA pan-cancer cohorts, B3GNT4 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of B3GNT4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where B3GNT4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types B3GNT4 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, HNSC, and LUAD are the cancer types where B3GNT4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in B3GNT4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	+2.273	<.001	12	view →
HNSC	Female	IV	+1.253	<.001	12	view →
LUAD	All	III,IV	+0.937	<.001	9	view →
COAD	Female	II,III,IV	+0.449	<.001	9	view →
LUSC	Female	All	+1.414	<.001	7	view →
BLCA	All	All	+0.901	<.001	7	view →
UCEC	All	All	+1.014	<.001	6	view →
KICH	All	All	−0.550	<.001	6	view →
STAD	All	II,III,IV	+0.318	.005	6	view →
LIHC	All	II,III,IV	+0.178	.001	6	view →
BRCA	Female	II,III,IV	+0.215	<.001	4	view →
CHOL	All	All	+0.611	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

B3GNT4–KIRC

Open the KIRC breakdown →