B3GNT3

Across TCGA patient cohorts, B3GNT3 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible B3GNT3-associated genes across cancer lineages are GSK3-a-b, FOXO3a, and Notch1. Each is linked with B3GNT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both B3GNT3-to-partner and partner-to-B3GNT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK3-a-b grouped by B3GNT3-low versus B3GNT3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (B3GNT3→partner) and Y-score (partner→B3GNT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GSK3-a-b →	-0.150	-2.584	.036	.011	3	1
UCEC	FOXO3a →	+0.157	+2.183	.003	.035	3	1
UCEC	Notch1 →	+0.179	+3.321	.015	.010	2	2
UCEC	14-3-3_epsilon →	+0.123	+3.009	.017	.019	3	1
UCEC	CDK1 →	-0.162	-3.321	.041	.010	3	1
SKCM	Src_pY416 →	+0.316	+3.000	.026	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

GSK3-a-b by B3GNT3 expression — SKCM

Explore this box plot interactively →