B3GNT3

Across TCGA pan-cancer cohorts, B3GNT3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of B3GNT3’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where B3GNT3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types B3GNT3 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

THCA, KICH, and LUAD are the cancer types where B3GNT3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in B3GNT3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	+5.397	<.001	11	view →
KICH	Female	II,III,IV	−4.537	<.001	11	view →
LUAD	Female	II,III,IV	+4.566	<.001	9	view →
BLCA	All	III,IV	+2.169	.023	8	view →
BRCA	Female	II,III,IV	−1.086	<.001	8	view →
LUSC	Male	All	+1.904	<.001	7	view →
LIHC	Female	All	+2.092	<.001	4	view →
STAD	All	All	+1.682	.002	4	view →
CHOL	Female	All	+5.910	<.001	3	view →
PAAD	All	All	+4.045	.019	2	view →
UCEC	All	All	+1.314	.031	2	view →
ESCA	All	II,III,IV	+1.270	.040	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

B3GNT3–THCA

Open the THCA breakdown →