AXIN2

Across TCGA patient cohorts, AXIN2 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AXIN2-associated genes across cancer lineages are PCNA, Annexin-1, and TIGAR. Each is linked with AXIN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AXIN2-to-partner and partner-to-AXIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by AXIN2-low versus AXIN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AXIN2→partner) and Y-score (partner→AXIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.148	+1.473	.025	.006	3	2
UCEC	Annexin-1 →	+0.464	+1.604	.003	.010	3	2
UCEC	TIGAR →	+0.115	+1.289	.014	.012	3	2
UCEC	YB-1 →	+0.120	+1.090	.013	.032	3	2
UCEC	Chk2_pT68 →	-0.132	-2.089	.020	.016	3	2
UCEC	C-Raf →	+0.118	+1.064	.007	.048	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

PCNA by AXIN2 expression — UCEC

Explore this box plot interactively →