AXIN2

Across TCGA cell cohorts, AXIN2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,596 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AXIN2-associated GO terms across cancer lineages are Regulation of mismatch repair, Negative regulation of gene expression, epigenetic, and Positive regulation of double-strand break repair. Each is linked with AXIN2 in more than 11 cancer types. Because this analysis shows association rather than direction, both AXIN2-to-partner and partner-to-AXIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mismatch repair grouped by AXIN2-low versus AXIN2-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AXIN2→partner) and Y-score (partner→AXIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Regulation of mismatch repair →	-0.196	-1.253	<.001	<.001	3	12
BLOOD_Lymphoma	Negative regulation of gene expression, epigenetic →	+0.060	+1.028	<.001	<.001	3	11
STOMACH	Positive regulation of double-strand break repair →	+0.077	+2.912	.009	.003	3	10
OVARY	Regulation of nucleotide-excision repair →	+0.110	+1.385	<.001	.007	3	10
URINARY_TRACT	Microtubule-based transport →	+0.052	+1.116	<.001	.007	3	10
OVARY	Positive regulation of DNA metabolic process →	+0.053	+1.642	<.001	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,596 associations by consensus.

Regulation of mismatch repair by AXIN2 expression — LUNG_NSCLC_LUAD

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