AXIN2

Across TCGA cell cohorts, AXIN2 mutation is significantly associated with the RNA expression of many other genes, with 680 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AXIN2-associated genes across cancer lineages are KSR2, ASZ1, and FAM160A1. Each is linked with AXIN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AXIN2-to-partner and partner-to-AXIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KSR2 grouped by AXIN2-low versus AXIN2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AXIN2→partner) and Y-score (partner→AXIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KSR2 →	+0.308	+3.061	<.001	.003	3	2
LUNG_NSCLC_LUAD	ASZ1 →	+0.422	+4.157	<.001	.003	3	2
LARGE_INTESTINE	FAM160A1 →	+0.713	+2.932	.001	<.001	3	2
LARGE_INTESTINE	CYB5A →	+0.824	+3.321	<.001	.002	3	2
LARGE_INTESTINE	RPSA →	+0.442	+2.458	.008	<.001	3	2
LARGE_INTESTINE	YBEY →	+0.575	+2.700	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 680 associations by consensus.

KSR2 by AXIN2 expression — BLOOD_Leukemia

Explore this box plot interactively →