AWAT2

Across TCGA patient cohorts, AWAT2 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AWAT2-associated genes across cancer lineages are PDCD4, ATM, and 14-3-3_beta. Each is linked with AWAT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AWAT2-to-partner and partner-to-AWAT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by AWAT2-low versus AWAT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AWAT2→partner) and Y-score (partner→AWAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.470	-1.440	.003	.024	3	2
UCEC	ATM →	-0.435	-1.440	.005	.024	3	2
UCEC	14-3-3_beta →	-0.091	-1.780	.009	.024	3	1
UCEC	eEF2 →	+0.299	+1.440	.015	.024	3	1
UCEC	EGFR_pY1068 →	-0.254	-2.087	.003	.005	3	1
UCEC	EGFR →	-0.172	-2.000	.001	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

PDCD4 by AWAT2 expression — UCEC

Explore this box plot interactively →