AWAT2

Across TCGA pan-cancer cohorts, AWAT2 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated AWAT2 data layer compared with 7 for mutation status.

The strongest signal is observed in kidney chromophobe (KICH), where higher AWAT2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated AWAT2 expression acts as an unfavorable survival marker, although some lineages such as PAAD and TGCT show a favorable association.

KICH, KIRC, and BRCA are the cancer types where AWAT2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Quartile	II,III,IV	0.342	0.887	<.001	65	view →
KIRC	DFS	Quartile	All	0.461	0.743	<.001	57	view →
BRCA	OS	Tertile	III,IV	0.459	0.732	.001	55	view →
PAAD	OS	Tertile	All	0.728	0.559	.015	50	view →
CHOL	DFS	Quartile	All	0.075	0.483	.002	40	view →
SCLC	DFS	Median	II,III,IV	0.266	0.570	.003	24	view →
UCS	OS	Quartile	III,IV	0.215	0.541	.017	18	view →
TGCT	DFS	Median	All	0.831	0.550	.001	18	view →
BLCA	DFS	Tertile	IV	0.612	0.277	.012	17	view →
SKCM	OS	Quartile	IV	0.802	0.215	.018	13	view →
READ	OS	Tertile	All	0.649	0.913	.029	12	view →
DLBC	DFS	Median	II,III,IV	1.000	0.366	.015	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

AWAT2–KICH (OS)

Open the KICH breakdown →