AWAT2

Across TCGA cell cohorts, AWAT2 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible AWAT2-associated genes across cancer lineages are GSX1, OR4X2, and OR4B1. Each is linked with AWAT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AWAT2-to-partner and partner-to-AWAT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSX1 grouped by AWAT2-low versus AWAT2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AWAT2→partner) and Y-score (partner→AWAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GSX1 →	+0.122	+4.887	<.001	.009	3	1
LUNG_SCLC	OR4X2 →	+0.045	+5.029	<.001	.006	3	1
LUNG_SCLC	OR4B1 →	+0.044	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

GSX1 by AWAT2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →