AURKB

Across TCGA cell cohorts, AURKB mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AURKB-associated genes across cancer lineages are APLNR, MSGN1, and S100G. Each is linked with AURKB in more than 1 cancer types. Because this analysis shows association rather than direction, both AURKB-to-partner and partner-to-AURKB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APLNR grouped by AURKB-low versus AURKB-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AURKB→partner) and Y-score (partner→AURKB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	APLNR →	+0.254	+3.799	<.001	.003	3	1
LARGE_INTESTINE	MSGN1 →	+0.080	+3.760	<.001	<.001	3	1
LARGE_INTESTINE	S100G →	+1.173	+3.103	<.001	.004	3	1
LARGE_INTESTINE	TFDP3 →	+0.018	+3.518	.001	.001	3	1
LARGE_INTESTINE	TAFA1 →	+0.241	+4.009	.001	<.001	3	1
LARGE_INTESTINE	C14orf180 →	+0.151	+3.155	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

APLNR by AURKB expression — LARGE_INTESTINE

Explore this box plot interactively →