AURKA

Across TCGA patient cohorts, AURKA mutation is significantly associated with the RNA expression of many other genes, with 833 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AURKA-associated genes across cancer lineages are PIGFP2, RNU1-35P, and RNU6-511P. Each is linked with AURKA in more than 1 cancer types. Because this analysis shows association rather than direction, both AURKA-to-partner and partner-to-AURKA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIGFP2 grouped by AURKA-low versus AURKA-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AURKA→partner) and Y-score (partner→AURKA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PIGFP2 →	+0.069	+5.771	<.001	.003	3	2
SKCM	RNU1-35P →	+0.502	+5.436	.001	.005	3	1
SKCM	RNU6-511P →	+0.400	+5.771	<.001	.003	3	1
SKCM	FGF7P7 →	+0.254	+5.867	<.001	.003	3	1
SKCM	OR6K5P →	+0.051	+5.037	<.001	.009	3	1
SKCM	MTCO3P2 →	+0.260	+5.159	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 833 associations by consensus.

PIGFP2 by AURKA expression — SKCM

Explore this box plot interactively →