AUH

Across TCGA patient cohorts, AUH mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AUH-associated genes across cancer lineages are EGFR_pY1068, INPP4B, and JNK2. Each is linked with AUH in more than 1 cancer types. Because this analysis shows association rather than direction, both AUH-to-partner and partner-to-AUH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by AUH-low versus AUH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AUH→partner) and Y-score (partner→AUH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.278	-2.999	.007	.035	3	1
UCEC	INPP4B →	-0.272	-2.459	.042	.019	3	1
UCEC	JNK2 →	+0.362	+3.000	<.001	.001	3	1
UCEC	Ku80 →	+0.195	+1.594	.046	.042	3	1
UCEC	NDRG1_pT346 →	-0.472	-2.321	.019	.034	3	1
UCEC	p21 →	+0.218	+2.321	.006	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

EGFR_pY1068 by AUH expression — UCEC

Explore this box plot interactively →