ATXN3L

Across TCGA patient cohorts, ATXN3L mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATXN3L-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and C-Raf. Each is linked with ATXN3L in more than 2 cancer types. Because this analysis shows association rather than direction, both ATXN3L-to-partner and partner-to-ATXN3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ATXN3L-low versus ATXN3L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATXN3L→partner) and Y-score (partner→ATXN3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.490	-3.156	.004	.018	3	3
UCEC	Caspase-7-cleavedD198 →	+0.575	+1.827	.011	.015	3	2
UCEC	C-Raf →	+0.171	+2.115	.001	.017	3	2
UCEC	A-Raf_pS299 →	-0.120	-2.807	.008	.003	3	1
UCEC	FASN →	+0.311	+2.000	.039	.030	3	1
UCEC	IGFBP2 →	-0.616	-2.321	.013	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

ATM by ATXN3L expression — UCEC

Explore this box plot interactively →