ATXN3L

Across TCGA cell cohorts, ATXN3L mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATXN3L-associated genes across cancer lineages are ECE2, ACER1, and KRT73. Each is linked with ATXN3L in more than 1 cancer types. Because this analysis shows association rather than direction, both ATXN3L-to-partner and partner-to-ATXN3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ECE2 grouped by ATXN3L-low versus ATXN3L-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATXN3L→partner) and Y-score (partner→ATXN3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ECE2 →	+0.381	+4.054	<.001	.004	3	1
LARGE_INTESTINE	ACER1 →	+0.157	+3.823	<.001	.006	3	1
LARGE_INTESTINE	KRT73 →	+0.084	+4.196	<.001	.002	3	1
LARGE_INTESTINE	CASP12 →	+0.033	+3.684	<.001	.006	3	1
LARGE_INTESTINE	TECRL →	+0.017	+4.562	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ECE2 by ATXN3L expression — LARGE_INTESTINE

Explore this box plot interactively →