ATXN3

Across TCGA cell cohorts, ATXN3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,807 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ATXN3-associated GO terms across cancer lineages are Monoubiquitinated protein deubiquitination, Vesicle tethering to Golgi, and Protein localization to condensed chromosome. Each is linked with ATXN3 in more than 18 cancer types. Because this analysis shows association rather than direction, both ATXN3-to-partner and partner-to-ATXN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Monoubiquitinated protein deubiquitination grouped by ATXN3-low versus ATXN3-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATXN3→partner) and Y-score (partner→ATXN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Monoubiquitinated protein deubiquitination →	+0.183	+1.185	<.001	<.001	3	19
OESOPHAGUS	Vesicle tethering to Golgi →	+0.122	+1.021	.002	<.001	3	16
URINARY_TRACT	Protein localization to condensed chromosome →	+0.154	+1.065	.004	.002	3	15
OVARY	Regulation of ERAD pathway →	+0.115	+1.056	<.001	<.001	3	15
BONE	Positive regulation of ERAD pathway →	+0.100	+0.796	.003	.003	3	14
STOMACH	Cellular response to misfolded protein →	+0.175	+1.236	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,807 associations by consensus.

Monoubiquitinated protein deubiquitination by ATXN3 expression — URINARY_TRACT

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