ATXN3

Across TCGA pan-cancer cohorts, ATXN3 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of ATXN3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ATXN3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ATXN3 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

HNSC, KICH, and LIHC are the cancer types where ATXN3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATXN3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+0.480	<.001	11	view →
KICH	Female	All	−0.741	<.001	8	view →
LIHC	All	II,III,IV	+0.267	<.001	7	view →
LUAD	Female	II,III,IV	−0.524	<.001	6	view →
BRCA	Female	All	−0.257	<.001	6	view →
CHOL	Male	All	+0.846	<.001	3	view →
THCA	All	All	−0.181	.003	3	view →
UCEC	All	All	−0.376	.001	2	view →
BLCA	Female	All	+0.219	.049	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

ATXN3–HNSC

Open the HNSC breakdown →