Across TCGA cell cohorts, ATXN2 mutation is significantly associated with the RNA expression of many other genes, with 344 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATXN2-associated genes across cancer lineages are AQP2, OR10W1, and FSHB. Each is linked with ATXN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATXN2-to-partner and partner-to-ATXN2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATXN2→partner) and Y-score (partner→ATXN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	AQP2 →	+0.024	+3.938	.008	.005	3	2
BREAST	OR10W1 →	+0.013	+5.781	<.001	.001	3	2
BLOOD_Lymphoma	FSHB →	+0.007	+3.925	<.001	.006	3	1
BLOOD_Lymphoma	OR1L4 →	+0.019	+2.874	.008	.009	3	1
BLOOD_Lymphoma	MBD3L4 →	+0.017	+2.874	.004	.009	3	1
LARGE_INTESTINE	PLA2G3 →	+0.888	+3.347	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 344 associations by consensus.

Exploration

ATXN2 survival (RNA) · tumor vs normal (RNA) · all ATXN2 data types