ATXN2-AS

Across TCGA pan-cancer cohorts, ATXN2-AS RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated ATXN2-AS data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ATXN2-AS RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ATXN2-AS expression acts as an unfavorable survival marker, although some lineages such as UCS and HNSC show a favorable association.

KIRC, UCS, and SKCM are the cancer types where ATXN2-AS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.733	0.843	<.001	127	view →
UCS	OS	Median	All	0.765	0.393	<.001	94	view →
SKCM	DFS	Tertile	All	0.653	0.869	.001	48	view →
MESO	OS	Quartile	All	0.407	0.650	.007	22	view →
HNSC	DFS	Tertile	II,III,IV	0.513	0.198	.009	20	view →
BLCA	OS	Median	All	0.680	0.551	.020	18	view →
UVM	DFS	Quartile	All	0.337	0.891	.012	18	view →
DLBC	DFS	Tertile	II,III,IV	1.000	0.376	.018	17	view →
BRCA	DFS	Tertile	All	0.863	0.925	.002	16	view →
PRAD	DFS	Quartile	All	0.829	0.933	.006	16	view →
ESCA	DFS	Median	All	0.414	0.586	.011	15	view →
LGG	OS	Median	All	0.869	0.917	.008	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

ATXN2-AS–KIRC (DFS)

Open the KIRC breakdown →