ATXN2-AS

Across TCGA pan-cancer cohorts, ATXN2-AS RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ATXN2-AS’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ATXN2-AS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ATXN2-AS is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

COAD, LIHC, and BLCA are the cancer types where ATXN2-AS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATXN2-AS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	+0.693	<.001	10	view →
LIHC	Male	II,III,IV	+0.849	<.001	9	view →
BLCA	All	III,IV	+0.581	<.001	9	view →
HNSC	Male	All	+0.269	.003	6	view →
STAD	All	All	+0.330	.003	4	view →
BRCA	Female	II,III,IV	+0.227	<.001	4	view →
PRAD	All	All	+0.696	<.001	2	view →
READ	Female	All	+0.690	.004	2	view →
KIRC	Male	All	−0.197	.010	2	view →
CHOL	All	All	+0.467	.008	1	view →
KICH	All	All	−0.349	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ATXN2-AS–COAD

Open the COAD breakdown →