ATXN1L

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, ATXN1L mutation is significantly associated with the total protein of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATXN1L-associated genes across cancer lineages are 14-3-3_beta, eIF4E, and A-Raf_pS299. Each is linked with ATXN1L in more than 1 cancer types. Because this analysis shows association rather than direction, both ATXN1L-to-partner and partner-to-ATXN1L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATXN1L→partner) and Y-score (partner→ATXN1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCEC14-3-3_beta →-0.125-3.295<.001<.00132
UCECeIF4E →+0.249+1.999<.001<.00132
UCECA-Raf_pS299 →-0.187-2.662<.001<.00132
UCECFOXO3a →-0.069-1.192.024.03232
COADINPP4B →-0.589-3.169<.001.01732
UCECMEK1 →+0.470+2.273<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

Exploration