Across TCGA pan-cancer cohorts, ATXN1L RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ATXN1L data layer compared with 6 for mutation status and 6 for mass-spec protein.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ATXN1L RNA is associated with better overall survival. In most high-consensus cancer types, elevated ATXN1L expression acts as an unfavorable survival marker, although some lineages such as KIRC and SCLC show a favorable association.
KIRC, BLCA, and SCLC are the cancer types where ATXN1L RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.