ATXN1

Across TCGA pan-cancer cohorts, ATXN1 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated ATXN1 data layer compared with 28 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ATXN1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ATXN1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, UCEC, and ACC are the cancer types where ATXN1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.021	0.712	<.001	24	view →
UCEC	DFS	Median	II,III,IV	0.869	0.428	.011	22	view →
ACC	DFS	Median	All	0.089	0.666	.017	6	view →
PRAD	DFS	Median	All	0.617	0.886	.035	6	view →
THCA	DFS	Median	All	0.224	0.843	.022	4	view →
KIRP	OS	Median	All	0.181	0.704	.009	4	view →
LUAD	OS	Median	II,III,IV	0.307	0.748	.046	3	view →
SKCM	OS	Median	III,IV	0.353	0.729	.032	3	view →
COAD	OS	Median	II,III,IV	0.521	0.797	.028	2	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

ATXN1–HNSC (OS)

Open the HNSC breakdown →